This data package consists of data from human islets (n=8) treated with IFNγ + IL-1β for 24 h and submitted to phosphoproteomics ( Table S1 ). Data contributor: Wei-Jun Qian: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99354, USA. Data repository: PXD011857...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα and RNAi targeting Poly(ADP)ribosyl polymerase 12 ( Parp12 ) for 24 h and submitted to proteomic analyses ( Table S1 ). PARP12 is an interferon-induced protein known to target viral RNA to stress granules. It...

This data package consists of data from human islets and EndoC-βH1 cells treated with IFNα for 2, 8, or 24 h and submitted to RNA-seq (human islets: n=6 & EndoC-βH1: n=5) and ATAC-seq (n=4). In parallel, a batch of cells (n=4) had proteomics, lipidomics, and metabolomics performed in the same...

This data package consists of data from MIN6 cells (n=3) treated with IFNγ + IL-1β + TNFα with or without DFMO or N1,N11-diethylnorspermine (DENSpm) and submitted to RNA-seq ( Table S1 ). DENSpm is an inhibitor of ornithine decarboxylase (ODC) and polyamine oxidase (PAOX), both enzymes in the...

This data package consists of mouse MIN6 cells treated with IL-1β + IFNγ + TNFα for 0 min, 15 min, 2 hr, and 24 hr, alongside an untreated 24 hr control, and submitted to global and PTM proteomics (carbamylation and acetylation) analysis (n=3) ( Table S1 ). This was designed to characterize the...

This data package consists of data from β-TC-6 cells treated with IFNγ + IL-1β for 4, 8 or 24 h (n=4) and submitted to enrichment of cysteine-containing peptides (redox), phosphopeptides and acetylated peptides. This enabled the analysis of proteomics, redox cysteine, phosphoproteomics and...

It consists of human islets (n=10, subdivided into 2 batches) treated with IFNγ + IL-1β for 24 h and submitted to proteomics, lipidomics and metabolomics in the same samples ( Table S1 ) Data contributors: Ernesto S. Nakayasu, Jennifer E. Kyle, Young-Mo Kim, Soumyadeep Sarkar & Thomas O. Metz...

This data package contains processed LC-MS proteomics results and analysis scripts associated with the paper "Assessment of Protein Inference Methods for Metaproteomics". In this study, we designed an artificial microbial community to create a simulated metaproteomic dataset which intentionally...

Dataset Description The goal of the experiment was to demonstrate that the optimized multiplexed multi-PTM profiling workflow can comprehensively and quantitatively capture dynamic changes in protein abundance, cysteine oxidation, phosphorylation, and acetylation in cytokine-induced inflammatory...

Dataset Description The purpose of this experiment was to evaluate the human host cellular response to wild type human coronavirus strain 229E (HCoV-229E) infection. Sample data was obtained for mock-infected and immortalized human lung fibroblasts (MRC-5) (MOI 5). Whole cell lysates were collected...

Currently pending public release.

Dataset Description The purpose of this experiment was to evaluate how wild-type Human coronavirus strain 229E (HCoV-299E) infection alters chromatin accessibility in infected cells. Sample data was obtained from mock-infected cells, UV-inactivated virus treated cells, and replication competent HCoV...

Dataset Description The purpose of this experiment was to evaluate the human host cellular response to wild-type Human coronavirus strain 229E (HCoV-299E) infection. Sample data was obtained for mock and infected (MOI 3) primary human airway epithelial cells with and without macrophages and grown in...

Dataset Description The purpose of this experiment was to evaluate the human host cellular response to wild-type Human coronavirus strain 229E (HCoV-229E) infection. Sample data was obtained for mock and infected immortalized human lung epithelial cells (A549) (MOI 5) nuclear extracts, immortalized...

Dataset Description The purpose of this experiment was to evaluate the human host cellular response to wild-type Human coronavirus strain 229E (HCoV-229E) infection. Sample data was obtained for mock and infected immortalized human lung epithelial cells (A549) (MOI 5), immortalized human lung...