It consists of human islets (n=10, subdivided into 2 batches) treated with IFNγ + IL-1β for 24 h and submitted to proteomics, lipidomics and metabolomics in the same samples ( Table S1 ) Data contributors: Ernesto S. Nakayasu, Jennifer E. Kyle, Young-Mo Kim, Soumyadeep Sarkar & Thomas O. Metz...

This data package consists of data from MIN6 cells treated with IL-1β + IFNγ + TNFα + palmitate for 24 h and submitted to proteomics analysis, and the same treatment for 8 h for metabolomics analysis (n=4) ( Table S1 ). This experimental design was set to study the possible roles of free fatty acids...

This data package consists of data from MIN6 cells (n=3) treated with IFNγ + IL-1β + TNFα with or without DFMO or N1,N11-diethylnorspermine (DENSpm) and submitted to RNA-seq ( Table S1 ). DENSpm is an inhibitor of ornithine decarboxylase (ODC) and polyamine oxidase (PAOX), both enzymes in the...

This data package consists of data from parallel experiments compared to Pck001 but performed with EndoC-βH1 cells instead of human islets. Cells were treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), DNA methylation (n=5), and H3K27Ac ChIP-seq (n=4). In addition...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα and RNAi targeting Poly(ADP)ribosyl polymerase 12 ( Parp12 ) for 24 h and submitted to proteomic analyses ( Table S1 ). PARP12 is an interferon-induced protein known to target viral RNA to stress granules. It...

This data package consists of data from β-TC-6 cells treated with IFNγ + IL-1β for 4, 8 or 24 h (n=4) and submitted to enrichment of cysteine-containing peptides (redox), phosphopeptides and acetylated peptides. This enabled the analysis of proteomics, redox cysteine, phosphoproteomics and...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post-RNAi targeting ADP-ribosylhydrolase ARH3 (Adprhl2), and submitted to proteomics analysis ( Table S1 ). ARH3 is a hydrolase that keeps cellular ADP-ribosylation levels in check and is regulated by...

This data package contains processed LC-MS proteomics results and analysis scripts associated with the paper "Assessment of Protein Inference Methods for Metaproteomics". In this study, we designed an artificial microbial community to create a simulated metaproteomic dataset which intentionally...

Dataset Description The goal of the experiment was to demonstrate that the optimized multiplexed multi-PTM profiling workflow can comprehensively and quantitatively capture dynamic changes in protein abundance, cysteine oxidation, phosphorylation, and acetylation in cytokine-induced inflammatory...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson MERS-CoV Experiment MCL005 Metadata The purpose of this experiment was to evaluate the human host epigenetic response to MERS-CoV virus infection. Samples were obtained from human lung adenocarcinoma cells (Calu-3) and processed for...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson MERS-CoV Experiment MCL004 Metadata The purpose of this experiment was to evaluate the host response to MERS-CoV virus infection. Sample data was obtained from human lung adenocarcinoma cells (Calu-3) and processed for genome binding/occupancy...

Omics-LHV, West Nile Experiment WGCN004 The purpose of this West Nile experiment was to obtain samples for omics analysis in primary mouse granule neuron cells infected with wild type West Nile virus (WNV-NY99 clone 382, WNVWT) and mutant virus (WNVE218A). Overall Design: Granule cell neurons from...

ProxyTSPRD profiles are collected using NVIDIA Nsight Systems version 2020.3.2.6-87e152c and capture computational patterns from training deep learning-based time-series proxy-applications on four different levels: models (Long short-term Memory and Convolutional Neural Network), DL frameworks...

Last updated on 2025-01-16T22:12:33+00:00 by LN Anderson Fungal Monoisolate Multi-Omics Data Package DOI "KS4A-Omics1.0_FspDS68" Molecular mechanisms underlying fungal mineral weathering and nutrient translocation in low nutrient environments remain poorly resolved, due to the lack of a platform for...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Influenza A Virus Experiment ICL106 Metadata The purpose of this experiment was to evaluate the human host epigenetic response to Influenza A virus (subtype H5N1) infection. Samples were obtained from human lung adenocarcinoma cell line (Calu...