The data package consists of RNA-seq datasets of EndoC-βH1 cells treated in parallel with IFNα, IFNγ, IL-1β and TNFα for 24 h and submitted to RNA-seq (n=4) ( Table 1 ) Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty, Université...

This data package consists data from EndoC-βH1 (n=6) treated with IFNα for 8 and 24 h and submitted to RNA-seq analysis ( Table 1 ). This was generated in parallel with Pck008. Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty...

This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq analysis ( Table 1 ). Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles...

This data package consists of RNA-seq data from human islets (n=10) treated with IFNγ + IL-1β for 24 h ( Table 1 ). Data contributors: Wenting Wu & Carmella Evans-Molina: Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. Farooq Syed: Center for...

It consists of human islets (n=10, subdivided into 2 batches) treated with IFNγ + IL-1β for 24 h and submitted to proteomics, lipidomics and metabolomics in the same samples ( Table 1 ) Data contributors: Ernesto S. Nakayasu, Jennifer Kyle, Young-Mo Kim, Soumyadeep Sarkar & Thomas O. Metz...

This data package consists of data from human islets and EndoC-βH1 cells treated with IFNα for 2, 8, or 24 h and submitted to RNA-seq (human islets: n=6 & EndoC-βH1: n=5) and ATAC-seq (n=4). In parallel, a batch of cells (n=4) had proteomics, lipidomics, and metabolomics performed in the same...

The data package consists of RNA-seq data from human islet-derived exosomes post IFNγ + IL-1β treatment of human islets (n=5) for 24 h ( Table 1 ). Data contributors: Preethi Krishnan& Carmella Evans-Molina: Department of Diabetes Immunology, Beckman Research Institute, City of Hope, Duarte, CA, USA...

This data package consists of data from human islets (n=8) treated with IFNγ + IL-1β for 24 h and submitted to phosphoproteomics ( Table 1 ). Data contributor: Wei-Jun Qian: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99354, USA. Data repository: PXD011857...

This data package consists of data from parallel experiments compared to Pck001 but performed with EndoC-βH1 cells instead of human islets. Cells were treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), DNA methylation (n=5), and H3K27Ac ChIP-seq (n=4). In addition...

This data package consists of data from human islets (n=6) treated with IFNγ + IL-1β for 24 h and submitted to top-down proteomics ( Table 1 ). Data contributors: Ashley Ives, Wei-Jun Qian & James Fulcher: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99354, USA...

This data package consists of data from paired human islets treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), UMI-4C18 (n=2 or 3, depending on the viewpoint), and ChIP-seq for histone H3 lysine 27 acetylation (H3K27Ac) (n=4) ( Table 1 ). Islets across the two studies...

This data package consists of data from sets of β-TC-3 cells (n=3) treated with IL-1β + IFNγ + TNFα for 24 h with or without ML351 and submitted to RNA-seq ( Table 1 ). ML351 is an inhibitor of 12-lipoxygenase, an enzyme that produces 12-HETE. Therefore, this treatment was done to study whether...

This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β with or without difluoromethylornithine (DFMO) and submitted to RNA-seq and proteomics analysis ( Table 1 ). DFMO is an inhibitor of ornithine decarboxylase (ODC), an enzyme of the polyamine pathway. Therefore, this...

This data package consists of data from MIN6 cells (n=3) treated with IFNγ + IL-1β + TNFα with or without DFMO or N1,N11-diethylnorspermine (DENSpm) and submitted to RNA-seq ( Table 1 ). DENSpm is an inhibitor of ornithine decarboxylase (ODC) and polyamine oxidase (PAOX), both enzymes in the...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post-RNAi targeting ADP-ribosylhydrolase ARH3 (Adprhl2), and submitted to proteomics analysis ( Table 1 ). ARH3 is a hydrolase that keeps cellular ADP-ribosylation levels in check and is regulated by...