This data package consists of data from sets of β-TC-3 cells (n=3) treated with IL-1β + IFNγ + TNFα for 24 h with or without ML351 and submitted to RNA-seq ( Table 1 ). ML351 is an inhibitor of 12-lipoxygenase, an enzyme that produces 12-HETE. Therefore, this treatment was done to study whether...

This data package consists of data from paired human islets treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), UMI-4C18 (n=2 or 3, depending on the viewpoint), and ChIP-seq for histone H3 lysine 27 acetylation (H3K27Ac) (n=4) ( Table 1 ). Islets across the study...

This data package consists of data from human islets treated for 48 h with cytokines (IFNγ, TNFα, and/or IL1β), thapsigargin (TG), brefeldin A (BFA), or DMSO for the control (CTRL) and submitted for single-cell RNA-seq (n=5) and single-nucleus multi-omics sequencing (snMultiomics-seq, n=1) ( Table 1...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα and RNAi targeting Poly(ADP)ribosyl polymerase 12 ( Parp12 ) for 24 h and submitted to proteomic analyses ( Table 1 ). PARP12 is an interferon-induced protein known to target viral RNA to stress granules. It...

This data package consists of data from parallel experiments compared to Pck001 but performed with EndoC-βH1 cells instead of human islets. Cells were treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), DNA methylation (n=5), and H3K27Ac ChIP-seq (n=4). In addition...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post-RNAi targeting ADP-ribosylhydrolase ARH3 (Adprhl2), and submitted to proteomics analysis ( Table 1 ). ARH3 is a hydrolase that keeps cellular ADP-ribosylation levels in check and is regulated by...

Please cite as : Mary S. Lipton, William C. Nelson, Hugh McCullough, Montana L. Smith, Sheryl L. Bell, Lisa M. Bramer, Hyun-Seob Song, Kirsten Hofmockel, 2025. Moisture Metaphenome Incubation Analysis Results . [Data Set] PNNL DataHub. https://doi.org/10.25584/3007775 This data is published under a...

RhizoGrid Indexed Sorghum Rhizosphere Multi-Omics Identification of spatially resolved biomarkers of drought in Sorghum bicolor rhizosphere molecular-microbe interactions using a novel root cartography "RhizoGrid" system for sampling plants under drought and control conditions across 10 equally...

This data package contains processed LC-MS proteomics results and analysis scripts associated with the paper "Assessing Degenerate Peptide Resolution Methods using a Ground Truth Dataset". In this study, we designed an artificial microbial community to create a ground truth, simulated metaproteomic...

Please cite as : Josué A. Rodríguez-Ramos, Amy E. Zimmerman, Ruonan Wu, Sheryl Bell, Trinidad Alfaro, Kirsten Hofmockel, William C. Nelson. 2025. Inter-Kingdom Viral Interactions. [Data Set] PNNL DataHub. https://doi.org/10.25584/2583337 This data is published under a CC0 license . The authors...

Please cite as : Robert E. Danczak, Sheryl Bell, Evan Warburton, Trinidad Alfaro, Kirsten Hofmockel, Amy E. Zimmerman, William C. Nelson, 2025. Prokaryotic and eukaryotic interactions along a moisture gradient . [Data Set] PNNL DataHub. https://doi.org/10.25584/2574929 This data is published under a...

Dataset Description The goal of the experiment was to demonstrate that the optimized multiplexed multi-PTM profiling workflow can comprehensively and quantitatively capture dynamic changes in protein abundance, cysteine oxidation, phosphorylation, and acetylation in cytokine-induced inflammatory...

Data package for Lipids represent a dynamic, yet stable pool of microbially-derived soil carbon This data is published under a CC0 license . The authors encourage data reuse and request attribution by referencing the below citations for the data packages and associated manuscript. Please cite as...

Please cite as : McClure, R. and Janet Jansson. 2025. EVT 16s Data and Large Supplementary Files . [Data Set] PNNL DataHub. https://doi.org/10.25584/2530740. This data is published under a CC0 license . The authors encourage data reuse and request attribution by referencing the above citations for...

This dataset includes numerical simulation results obtained with the E3SMv2 model using the F2010 configuration (’‘compset’’) at the ne30pg2 horizonal resolution with 72 vertical grid layers in the atmosphere. The simulations were nudged to the ERA-Interim reanalysis. Pairs of simulations were...