This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β with or without difluoromethylornithine (DFMO) and submitted to RNA-seq and proteomics analysis ( Table 1 ). DFMO is an inhibitor of ornithine decarboxylase (ODC), an enzyme of the polyamine pathway. Therefore, this...

This data package consists of data from human islets (n=6) treated with IFNγ + IL-1β for 24 h and subjected to top-down proteomics ( Table 1 ). Data contributors: Ashley N. Ives, Wei-Jun Qian & James M. Fulcher: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99354...

This data package consists of data from sets of β-TC-3 cells (n=3) treated with IL-1β + IFNγ + TNFα for 24 h with or without ML351 and submitted to RNA-seq ( Table 1 ). ML351 is an inhibitor of 12-lipoxygenase, an enzyme that produces 12-HETE. Therefore, this treatment was done to study whether...

This data package consists of data from parallel experiments compared to Pck001 but performed with EndoC-βH1 cells instead of human islets. Cells were treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), DNA methylation (n=5), and H3K27Ac ChIP-seq (n=4). In addition...

This data package consists of data from MIN6 cells treated with IL-1β + IFNγ + TNFα + palmitate for 24 h and submitted to proteomics analysis, and the same treatment for 8 h for metabolomics analysis (n=4) ( Table 1 ). This experimental design was set to study the possible roles of free fatty acids...

This data package consists of data from β-TC-6 cells treated with IFNγ + IL-1β for 4, 8 or 24 h (n=4) and submitted to enrichment of cysteine-containing peptides (redox), phosphopeptides and acetylated peptides. This enabled the analysis of proteomics, redox cysteine, phosphoproteomics and...

This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq analysis ( Table 1 ). Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles...

This data package contains processed LC-MS proteomics results and analysis scripts associated with the paper "Assessing Degenerate Peptide Resolution Methods using a Ground Truth Dataset". In this study, we designed an artificial microbial community to create a ground truth, simulated metaproteomic...

Dataset Description The goal of the experiment was to demonstrate that the optimized multiplexed multi-PTM profiling workflow can comprehensively and quantitatively capture dynamic changes in protein abundance, cysteine oxidation, phosphorylation, and acetylation in cytokine-induced inflammatory...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson MERS-CoV Experiment MCL004 Metadata The purpose of this experiment was to evaluate the host response to MERS-CoV virus infection. Sample data was obtained from human lung adenocarcinoma cells (Calu-3) and processed for genome binding/occupancy...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson MERS-CoV Experiment MCL005 Metadata The purpose of this experiment was to evaluate the human host epigenetic response to MERS-CoV virus infection. Samples were obtained from human lung adenocarcinoma cells (Calu-3) and processed for...

Omics-LHV, West Nile Experiment WGCN004 The purpose of this West Nile experiment was to obtain samples for omics analysis in primary mouse granule neuron cells infected with wild type West Nile virus (WNV-NY99 clone 382, WNVWT) and mutant virus (WNVE218A). Overall Design: Granule cell neurons from...

Last updated on 2025-01-16T22:12:33+00:00 by LN Anderson Fungal Monoisolate Multi-Omics Data Package DOI "KS4A-Omics1.0_FspDS68" Molecular mechanisms underlying fungal mineral weathering and nutrient translocation in low nutrient environments remain poorly resolved, due to the lack of a platform for...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Influenza A Virus Experiment ICL105 Metadata The purpose of this experiment was to evaluate the host epigenetic response to Influenza A virus (subtype H5N1) infection. Sample data was obtained from human lung adenocarcinoma cells (Calu-3) and...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Influenza A Virus Experiment ICL106 Metadata The purpose of this experiment was to evaluate the human host epigenetic response to Influenza A virus (subtype H5N1) infection. Samples were obtained from human lung adenocarcinoma cell line (Calu...