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The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...

Reusable Digital Data Lifecycle Downloads for Omics-Lethal Human Virus Systems Biology The Omics-LHV Systems Virology project was one of four projects, funded by the NIAID Systems Biology for Infectious Diseases Research Program (funded from 2008-2013), was established in developing and validating...

Integrative Omics

Datasets
11

The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...

Omics-LHV Systems Biology Modeling Host Response to Severe Acute Respiratory Syndrome (SARS) Infection The Systems Virology project was one of four systems biology contracts funded by the NIAID Systems Biology for Infectious Diseases Research Program from 2008-2013. The Systems Biology for...

Integrative Omics

Datasets
11

Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...

Systems Virology Lethal Human Virus, SARS-CoV Experiment SHAE004 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome analysis in Human Airway Epithelial (HAE) cells infected with SARS-CoV, SARS deltaORF6, SARS BatSRBD mutants in a longitudinal study...

Omics-LHV, MERS Experiment MCL003 The purpose of this MERS experiment was to obtain samples for omics analysis of human Calu-3 cell response to treated with wild-type icMERS-CoV and mockulum. For proteomics, lipidomics, and metabolomics data from the Calu-3 cells infected with MERS-CoV, the...

Reusable Digital Data Lifecycle Downloads for Modeling Host Responses to Understand Severe Human Virus Infections The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" (U19AI106772) program project was a highly...

Integrative Omics

Datasets
50

Influenza A Experiment IM104 Processed Omics Data Unavailable This Influenza experiment evaluated mouse lung expression after etoposide treatment and infection with a pandemic H1N1 influenza strain. Related Experimental Data BioProject: PRJNA382278 GEO: GSE97555 (mRNA transcriptome response)...

Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...

The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD...

Ebola Experiment EH001 The purpose of this experiment was to evaluate the human patient peripheral blood mononuclear cells (PBMC) response to Zaire Ebola Makona virus infection during the 2013-2016 epidemic in West Africa. Sample were obtained from whole blood collections from patients and...

Integrative Omics

Omics-LHV, West Nile Experiment WLN002 The purpose of this West Nile experiment was to obtain serum samples for transcriptome analysis in mouse popliteal draining lymph nodes (DLN) infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall...

Omics-LHV, West Nile Experiment WCT001 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cortex tissue infected with wild-type West Nile Virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall Design: Mice were inoculated with WNV...

Omics-LHV, West Nile Experiment WCB001 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cerebellum tissue infected with wild-type West Nile Virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall Design: Mice were inoculated with...