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Reusable Digital Data Lifecycle Downloads for Modeling Host Responses to Understand Severe Human Virus Infections The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" (U19AI106772) program project was a highly...

Integrative Omics

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Influenza A Experiment IM104 Processed Omics Data Unavailable This Influenza experiment evaluated mouse lung expression after etoposide treatment and infection with a pandemic H1N1 influenza strain. Related Experimental Data BioProject: PRJNA382278 GEO: GSE97555 (mRNA transcriptome response)...

Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...

The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD...

Ebola Experiment EH001 The purpose of this experiment was to evaluate the human patient peripheral blood mononuclear cells (PBMC) response to Zaire Ebola Makona virus infection during the 2013-2016 epidemic in West Africa. Sample were obtained from whole blood collections from patients and...

Integrative Omics

Omics-LHV, West Nile Experiment WLN002 The purpose of this West Nile experiment was to obtain serum samples for transcriptome analysis in mouse popliteal draining lymph nodes (DLN) infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall...

Omics-LHV, West Nile Experiment WCT001 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cortex tissue infected with wild-type West Nile Virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall Design: Mice were inoculated with WNV...

Omics-LHV, West Nile Experiment WCB001 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cerebellum tissue infected with wild-type West Nile Virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall Design: Mice were inoculated with...

Influenza A Experiment IM103 The purpose of this experiment was to evaluate the human host response to wild-type Influenza A/Vietnam/1203/2004 (H5N1; VN1203) virus infection and mock infection. Sample data was obtained for mouse lung tissue for mRNA, miRNA, proteomics, lipidomics, and metabolomics...

Integrative Omics

Influenza A Experiment IM102 The purpose of this Influenza experiment was to obtain samples for mRNA, miRNA, proteomics, lipidomics, and metabolomics analysis in mouse lung infected with WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus). Overall Design: Groups...

Integrative Omics

Influenza A Experiment IM101 The purpose of this experiment was to evaluate the Mus musculus host response to Influenza A wild-type (A/Vietnam/1203/2004; H5N1 | A/California/04/2009; H1N1) virus and H5N1 mutant virus (PB2-627E, NS1trunc124) infection. Sample data was obtained for mouse lung...

Integrative Omics

Influenza A Experiment ICL104 The purpose of this experiment was to evaluate the host response to Influenza A pandemic wild-type H1N1 (A/California/04/2009), natural isolate virus. Sample data was obtained for human Calu-3 cells infected with wild-type H1N1 virus (A/California/04/2009) for mRNA...

Integrative Omics

Influenza A Experiment ICL103 The purpose of this experiment was to evaluate the human host response to Influenza A wild-type (H5N1) virus and mutant viruses. Sample data was obtained for human lung adenocarcinoma cell line (Calu-3) infected with WT Influenza A/Vietnam/1203/2004 (H5N1, VN1203) and...

Integrative Omics

Influenza A Experiment ICL102 The purpose of this experiment was to evaluate the human host cellular response to wild-type Influenza A/Anhui/1/2013 (H7N9; "AH1-WT") virus and NS1-L103F/I106M ("AH1-F/M") and partially ferret-adapted ("AH1-691") mutant virus infection. Sample data was obtained from...

Integrative Omics

Ebola Experiment EU937001 The purpose of this experiment was to evaluate the human host response to Zaire Ebola wild-type virus and mutant virus infection. Samples were obtained from human histiocytic lymphoma cells (U937), expressing the Ebola VP30 protein, infected with wild-type Zaire Ebola (in...