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Showing 151 - 165 of 321
Dataset
Omics-Lethal Human Viruses, West Nile Experiment WCN002

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson West Nile Virus Experiment WCN002 The purpose of this experiment was to evaluate the host response to West Nile virus (strain WNV-NY99) wild-type clone 382 and mutant 382-E218A virus infection. Sample data was obtained from mouse (strain C57BL...

Biology
Human Health
Integrative Omics
Publication
The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections
Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
Biology
Human Health
Publication
Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
Biology
Human Health
Publication
Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury
Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
Biology
Human Health
Publication
Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells
The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...
Biology
Human Health
Publication
A comprehensive collection of systems biology data characterizing the host response to viral infection
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...
Biology
Human Health
Publication
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses
Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
Biology
Human Health
Dataset
Systems Virology Lethal Human Virus, SARS-CoV Experiment SHAE004

Systems Virology Lethal Human Virus, SARS-CoV Experiment SHAE004 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome analysis in Human Airway Epithelial (HAE) cells infected with SARS-CoV, SARS deltaORF6, SARS BatSRBD mutants in a longitudinal study...

Biology
Human Health
Publication
Validation of the Community Land Model Version 5 over the Contiguous United States (CONUS) using in-situ and remote sensing datasets
The Community Land Model (CLM) is an effective tool to simulate the biophysical and biogeochemical processes and their interactions with the atmosphere. Although CLM Version 5 (CLM5) constitutes various updates in these processes, its performance in simulating energy, water and carbon cycles over...
Atmospheric Science
Dataset
Omics-Lethal Human Viruses, MERS-CoV Experiment MCL003

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson MERS-CoV Experiment MCL003 The purpose of this experiment was to evaluate the human host response to wild-type infectious clone of Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV) infection and mockulum. Sample data was obtained...

Biology
Human Health
Integrative Omics
Project
NIAID Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection Background The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host...

Biology
Human Health
Integrative Omics

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Dataset
Omics-Lethal Human Viruses, Influenza A Experiment IM104

Influenza A Experiment IM104 Processed Omics Data Unavailable This Influenza experiment evaluated mouse lung expression after etoposide treatment and infection with a pandemic H1N1 influenza strain. Related Experimental Data BioProject: PRJNA382278 GEO: GSE97555 (mRNA transcriptome response)...

Biology
Human Health
Integrative Omics
Publication
MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...
Biology
Human Health
Publication
Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis
The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD...
Biology
Human Health
Dataset
Omics-Lethal Human Viruses, Ebola Experiment EH001

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Ebola Virus Experiment EH001 The purpose of this experiment was to evaluate the human patient peripheral blood mononuclear cells (PBMC) response to Zaire Ebola virus (strain Makona) infection during the 2013-2016 epidemic in West Africa...

Biology
Human Health
Integrative Omics