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Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...

The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...

Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...

The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...

Reusable Digital Data Lifecycle Downloads for Omics-Lethal Human Virus Systems Biology The Omics-LHV Systems Virology project was one of four projects, funded by the NIAID Systems Biology for Infectious Diseases Research Program (funded from 2008-2013), was established in developing and validating...

Integrative Omics

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The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...

Omics-LHV Systems Biology Modeling Host Response to Severe Acute Respiratory Syndrome (SARS) Infection The Systems Virology project was one of four systems biology contracts funded by the NIAID Systems Biology for Infectious Diseases Research Program from 2008-2013. The Systems Biology for...

Integrative Omics

Datasets
11

Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...

Systems Virology Lethal Human Virus, SARS-CoV Experiment SHAE004 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome analysis in Human Airway Epithelial (HAE) cells infected with SARS-CoV, SARS deltaORF6, SARS BatSRBD mutants in a longitudinal study...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson MERS-CoV Experiment MCL003 The purpose of this experiment was to evaluate the human host response to wild-type infectious clone of Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV) infection and mockulum. Sample data was obtained...

Integrative Omics

Last updated on 2023-05-05T16:36:07+00:00 by LN Anderson PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to...

Integrative Omics

Datasets
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Influenza A Experiment IM104 Processed Omics Data Unavailable This Influenza experiment evaluated mouse lung expression after etoposide treatment and infection with a pandemic H1N1 influenza strain. Related Experimental Data BioProject: PRJNA382278 GEO: GSE97555 (mRNA transcriptome response)...

Integrative Omics

Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...

The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson Ebola Virus Experiment EH001 The purpose of this experiment was to evaluate the human patient peripheral blood mononuclear cells (PBMC) response to Zaire Ebola Makona virus infection during the 2013-2016 epidemic in West Africa. Samples were...

Integrative Omics