Influenza A Experiment ICL103 The purpose of this experiment was to evaluate the human host response to Influenza A wild-type (H5N1) virus and mutant viruses. Sample data was obtained for human lung adenocarcinoma cell line (Calu-3) infected with WT Influenza A/Vietnam/1203/2004 (H5N1, VN1203) and...
Influenza A Experiment ICL102 The purpose of this experiment was to evaluate the human host cellular response to wild-type Influenza A/Anhui/1/2013 (H7N9; "AH1-WT") virus and NS1-L103F/I106M ("AH1-F/M") and partially ferret-adapted ("AH1-691") mutant virus infection. Sample data was obtained from...
Ebola Experiment EHUH002 The purpose of this experiment was to evaluate the human host response to Zaire Ebola wild-type virus and mutant virus infection. Samples were obtained from human hepatoma carcinoma cells (HUH-7) infected with Zaire Ebola ΔVP30-WT background for proteome, metabolome, and...
Ebola Experiment EHUH001 The purpose of this experiment was to evaluate the human host response to Zaire Ebola wild-type virus and mutant virus infection. Samples were obtained from human hepatoma carcinoma cells (HUH-7) infected with Zaire Ebola ΔVP30-WT background, in addition to mutant viruses...
MERS-CoV Experiment MCL001 The purpose of this experiment was to evaluate the human host cellular response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-CoV-RFP, icMERS-CoV-dNSP16, icMERS-CoV-d4B, and icMERS-CoV-d3 virus infection. Sample time...
Interferon Experiment IFNaHUH001 The purpose of this experiment was to evaluate the human host cellular response to treatment with and without interferon alpha beta (IFNαβ) treatment. Sample time course data was obtained from human hepatoma carcinoma cells (HUH-7) expressing transcriptional...
Interferon Experiment IFNMVE001 The purpose of this experiment was to evaluate the host interferon-stimulated cellular response to human interferon alpha beta (IFNαβ) or gamma (INFγ) treatment. Sample data was obtained from human primary lung microvascular endothelial (MVE) cells treated with or...
Interferon Experiment FNαCL001 The purpose of this experiment was to evaluate the host interferon-stimulated cellular response to human interferon alpha (IFNα) treatment. Sample data was obtained from human lung adenocarcinoma cells (Calu-3) treated with or without IFNα for mRNA and miRNA...
Omics-LHV Profiling of Host Response to West Nile Virus Infection Background: West Nile virus (WNV) is classified as a Category B priority pathogen, by the National Institute of Allergy and Infectious Diseases (NIAID), and are known to cause severe and even fatal infections in humans where lethal...
Omics-LHV Profiling of Host Response to Ebola Virus Infection Background Ebola virus (EBOV) is high risk biological agent classified as a Category A priority pathogen by the National Institute of Allergy and Infectious Diseases (NIAID) and is known to cause severe respiratory disease or hemorrhagic...
Omics-LHV Profiling of Host Response to MERS-CoV Virus Infection Background: Middle East Respiratory Syndrome coronavirus (MERS-CoV) is classified as a Category C priority pathogen, by the National Institute of Allergy and Infectious Diseases (NIAID), and are known to cause severe and even fatal...
Omics-LHV Profiling of Host Interferon-Stimulated Response to Virus Infection Data Reuse & Impact: Omics-LHV PNNL sub-projects provide a never before released comprehensive human interferon response collection of primary and secondary transformation multi-Omics data profiling a series of priority...
This project is an interdisciplinary collaboration supported by US DOE Office of Science's Scientific Discovery through Advanced Computing (SciDAC) program. The project addresses a crucial but largely overlooked source of error in the Energy Exascale Earth System Model (E3SM) and other atmosphere...
