Machine learning is a core technology that is rapidly advancing within type 1 diabetes (T1D) research. Our Human Islet Research Network (HIRN) grant is studying early cellular response initiating β cell stress in T1D through the generation of heterogenous low- and high-throughput molecular...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Janet Jansson is Chief Scientist for Biology in the Biological Sciences Division and a Laboratory Fellow at the Pacific Northwest National Laboratory (PNNL). Jansson has more than 30 years of experience in microbial ecology. Jansson earned an M.S.in Soil Microbiology at Colorado State University...

Hyun Song’s research is directed toward developing modeling and computational tools for the simulation of cellular metabolism and microbial community dynamics. His research interest in metabolic modeling includes 1) omics data-guided estimation of flux distribution in a genome-scale metabolic...

Aaron Wright leads the Chemical Biology & Exposure Sciences Group in the Biological Sciences Division at PNNL. His highly collaborative and diverse chemical biology research team is focused on gaining an improved functional and mechanistic understanding of biological processes including: (a)...

PNNL Publications 2020 Smith J.N., K.J. Tyrrell, J.P. Smith, J.P. Smith, K.K. Weitz, and W.D. Faber. 2020. "Linking Internal Dosimetries of the Propyl Metabolic Series in Rats and Humans Using Physiologically Based Pharmacokinetic (PBPK) Modeling." Regulatory Toxicology and Pharmacology 110. PNNL...

The Environmental Determinants of Diabetes in the Young (TEDDY) study is searching for factors influencing the development of type 1 diabetes (T1D) in children. Research has shown that there are certain genes that correlate to higher risk of developing T1D, but not all children with these genes...

The Diabetes Autoimmunity Study in the Young (DAISY) seeks to find environmental factors that can trigger the development of type 1 diabetes (T1D) in children. DAISY follows children with high-risk of developing T1D based on family history or genetic markers. Genes, diets, infections, and...

Publications: 2018 Khan NE, Y Maezato, RS McClure, CJ Brislawn, JM Mobberley, NG Isern, WB Chrisler, LM Markillie, BM Barney, HS Song, WC Nelson, and HC Bernstein. 2018. "Phenotypic responses to interspecies competition and commensalism in a naturally-derived microbial co-culture." Scientific...

Chris received his Bachelor of Science degree in chemistry at the University of Colorado at Colorado Springs in 2005. He attained his PhD in chemistry at the University of Illinois at Urbana–Champaign in 2011, under Mary L. Kraft, where his graduate work focused on using secondary ion mass...

Biography Dr. Mary Lipton is currently a Staff Scientist at the Pacific Northwest National Laboratory and Adjunct Professor at Washington State University-Tri-Cities in Richland and Adjunct Professor in the Institute for Biological Chemistry and Washington State University Pullman. She is nationally...

Tom Metz is a Principal Investigator within the Integrative Omics group at PNNL and the Metabolomics Team Lead for a group of scientists that focuses on development and applications of high throughput metabolomics and lipidomics methods to various biological questions. He has worked to develop state...

Michelle Davison is a microbiologist with a love of challenging, creative, and multidisciplinary projects. She is interested in the role phage play in environmental systems, as well as the myriad ways they can be harnessed as tools. She has experience isolating, developing and working with non-model...

PNNL Publications 2020 Ogden A.J., T.W. Wietsma, T.E. Winkler, Y. Farris, G.L. Myers, and A. Ahkami. 2020. "Dynamics of Global Gene Expression and Regulatory Elements in Growing Brachypodium Root System." Scientific Reports 10. PNNL-SA-145907. doi:10.1038/s41598-020-63224-z 2019 Boiteau R.M., S.J...

Spruce and Peatlands Responses Under Changing Environments (SPRUCE) site is the 8.1-ha S1 bog, a Picea mariana [black spruce] – Sphagnum spp. ombrotrophic bog forest in northern Minnesota, 40 km north of Grand Rapids, in the USDA Forest Service Marcell Experimental Forest (MEF). Two field research...