The data accompanies the manuscript that evaluates salinity-associated shifts in organic C thermodynamics, biochemical transformations, and heteroatom content in a first-order coastal watershed in the Olympic Peninsula of Washington state, USA. The files contain raw data including soil chemical...
Problem Statement and Objectives : Climate datasets are available across many institutions. Understanding which one to use, or how to combine the datasets, and for which application, or/and which region, and/or which specific fundamental science question is a challenge. A multi-lab PNNL-ANL...
Background In type 1 diabetes (T1D), autoimmune response and inflammation cause the death of pancreatic β cells, leading to the body’s inability to produce insulin and maintain glucose homeostasis. This process is at least in part mediated by pro-inflammatory cytokines, such as interferon (IFN)α...
Current methods for supply chain inventory data often require significant time and effort from manufacturers to compile. Additionally, without a uniform methodology these can result in inconsistent datasets that are difficult for practitioners to evaluate and compare, even within similar product...
This study investigates how circadian clock regulation impacts carbon partitioning between storage, growth, and product synthesis in Synechococcus elongatus PCC 7942 in providing insights for potential strategies for enhanced bioproduction. In our analysis we explore circadian regulatory rewiring of...
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually causing local outbreaks and epidemics. While all three newly...
The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma. Previously, we found that lipidated HDL containing both apolipoprotein A-I (APOA1) and A-II (APOA2) promotes...
The overarching goal of this research is to predict and engineer robust microbial phenotypes under stressed conditions to accelerate and de-risk bioprocess development. Laboratory strains routinely fail to maintain productivity at industrial scales, in part due to bioprocess stresses and a limited...
The research goal of this project is to develop a computational approach known as Variation-leveraged Phenomic Association Study (VaLPAS) to address the challenge of using functional dark matter (proteins, metabolites, lipids) for bioeconomy applications. The project has four objectives: 1...
Climate change is expected to increase the frequency of hotter and more intense droughts accompanied by aberrant precipitation events. Such extreme environmental shifts can trigger a complex cascade of microbial physiological responses that can impact the microbial community structure and functions...
Please cite as: Graham E.B., and K.S. Hofmockel. 2021. "Ecological stoichiometry as a foundation for omics-enabled biogeochemical models of soil organic matter decomposition." Biogeochemistry 157. doi:10.1007/s10533-021-00851-2 Coupled biogeochemical cycles drive ecosystem ecology by influencing...
Soil viruses are highly abundant and have important roles in the regulation of host dynamics and soil ecology. Climate change is resulting in unprecedented changes to soil ecosystems and the life forms that reside there, including viruses. In this Review, we explore our current understanding of soil...
Metagenomics is unearthing the previously hidden world of soil viruses. Many soil viral sequences in metagenomes contain putative auxiliary metabolic genes (AMGs) that are not associated with viral replication. Here, we establish that AMGs on soil viruses actually produce functional, active proteins...