The research goal of this project is to develop a biologically informed machine learning (ML) model that integrates datasets from different studies, and leverages current biological knowledge in an automated manner, to improve predictions in biological data analysis.
The research goal of this project is to build and understand model communities that show carbon storage phenotypes
The research goal of this project is to develop computational methods to predict cell regulation phenotypes using small molecule and proteome data to understand outcomes in complex biological systems.
The research goal of this project is to develop new theory and tools that leverage evolutionary perspectives and knowledge of the energetics of reactions to predict the most likely regulation in a given environment. These methods will accelerate exploration, modeling and understanding of cell...
By developing explainable, predictive metabolic models of individual microbes, we aim to design consortia that convert light and abundant atmospheric gases into high-value molecules through microbial division of labor.
The research goal of this project is to identify and control host functions hijacked during viral infection through use of PNNL ‘omics technologies and modeling capabilities.
The research goal of this project is to construct and streamline an approach to identify phenotype-relevant signatures by integrating various proteomics data. Leveraging protein structures and interaction networks, we will map structural changes and post-translational modifications to identify...
The research objective of this project is to develop an integrative and automated multi-PTM profiling capability with deep proteome coverage.
The research goal of this project is to use stimuli-specific, synthetic nanobodies to target functional mediators without prior knowledge of the response networks or manipulating the biological system.
The science objective of this project is to apply structural proteomics technologies to map the molecular interactome.
The Human Islet Research Network (HIRN) is a large consortia with many research projects focused on understanding how beta cells are lost in type 1 diabetics (T1D) with a goal of finding how to protect against or replace the loss of functional beta cells. The consortia has multiple branches of...
Predictive Phenomics Initiative (PPI) Project Data Catalog Collection The Predictive Phenomics Initiative (PPI) is an internal LDRD investment at Pacific Northwest National Laboratory focused on unraveling the mysteries of molecular function in complex biological systems. Explore PPI research...
The science objectives of this project are to: Functionally enrich microbial communities and generate multi-omics to correlate biochemical mechanisms to activity. Integrate PhenoProfiling with Thrust Areas 2 and 3 to develop models for phenotype prediction and interspecies interactions. Evaluate...
Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host...
PNNL’s Vision Statement for Equity in the Power Grid Drawing from a wealth of interdisciplinary research in grid modernization, PNNL is spearheading an effort to advance equity and energy justice through the role of scientific research with the goal of building an advanced national power grid...
